Recent Publications

For a complete list of publications, please visit PubMed.


Alteri CJ, Himpsl SD, Shea AE, Mobley HLT. Flexible metabolism and suppression of latent enzymes are important for E. coli adaptation to diverse environments within the host. J Bacteriol. 2019 Jun 3;. doi: 10.1128/JB.00181-19. [Epub ahead of print] PubMed PMID: 31160397.

Armbruster CE, Forsyth VS, Johnson AO, Smith SN, White AN, Brauer AL, Learman BS, Zhao L, Wu W, Anderson MT, Bachman MA, Mobley HLT. Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection. PLoS Pathog. 2019 Apr;15(4):e1007653. doi: 10.1371/journal.ppat.1007653. eCollection 2019 Apr. PubMed PMID: 31009518; PubMed Central PMCID: PMC6497324.


Waack U, Warnock M, Yee A, Huttinger Z, Smith S, Kumar A, Deroux A, Ginsburg D, Mobley HLT, Lawrence DA, Sandkvist M. CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII. MBio. 2018 Dec 18;9(6). pii: e01606-18. doi: 10.1128/mBio.01606-18. PMID: 30563903.

Luterbach CL, Mobley HLT. Cross Talk between MarR-Like Transcription Factors Coordinates the Regulation of Motility in Uropathogenic Escherichia coli. Infect Immun. 2018;86(12):e00338-18. Published 2018 Nov 20. doi:10.1128/IAI.00338-18; PMCID: PMC6246914.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT. Citrobacter freundii fitness during bloodstream infection. Sci Rep. 2018 Aug 7;8(1):11792. doi: 10.1038/s41598-018-30196-0. PubMed PMID: 30087402; PubMed Central PMCID: PMC6081441.

Debnath I, Stringer AM, Smith SN, Bae E, Mobley HLT, Wade JT, Pearson MM. MrpJ Directly Regulates Proteus mirabilis Virulence Factors Including Fimbriae and Type VI Secretion During Urinary Tract Infection. Infect Immun. 2018 Aug 6. pii: IAI.00388-18. doi: 10.1128/IAI.00388-18. [Epub ahead of print] PubMed PMID: 30082479.

Armbruster CE, Smith SN, Mody L, Mobley HLT. Urine cytokine and chemokine levels predict urinary tract infection severity independent of uropathogen, urine bacterial burden, host genetics, and host age. Infect Immun. Aug 2018, 86 (9) e00327-18; doi: 10.1128/IAI.00327-18. PubMed Central PMID: 29891542.

Crépin S, Ottosen EN, Peters K, Smith SN, Himpsl SD, Vollmer W, Mobley HLT. The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii. Mol Microbiol. 2018;109(6):745-762. ; PubMed Central PMCID: PMC6185781.

Luterbach CL, Forsyth VS, Engstrom MD, Mobley HLT. TosR-Mediated Regulation of Adhesins and Biofilm Formation in Uropathogenic Escherichia coli. mSphere. 2018;3(3):e00222-18. Published 2018 May 16. doi:10.1128/mSphere.00222-18. ; PubMed Central PMCID: PMC5956150.

Forsyth VS, Armbruster CE, Smith SN, Pirani A, Springman AC, Walters MS, Nielubowicz GR, Himpsl SD, Snitkin ES, Mobley HLT.. Rapid Growth of Uropathogenic Escherichia coli during Human Urinary Tract Infection. MBio. 2018 Mar 6;9(2)PubMed PMID: 29511075; PubMed Central PMCID: PMC5844997.

Sintsova A, Smith S, Subashchandrabose S, Mobley HL. Role of Ethanolamine Utilization Genes in Host Colonization during Urinary Tract Infection. Infect Immun. 2018 Mar;86(3)PubMed PMID: 29229730; PubMed Central PMCID: PMC5820945.

Dbeibo L, van Rensburg JJ, Smith SN, Fortney KR, Gangaiah D, Gao H, Marzoa J, Liu Y, Mobley HLT, Spinola SM. Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections. Infect Immun. 2018 Mar;86(3)PubMed PMID: 29311237; PubMed Central PMCID: PMC5820967.

Armbruster CE, Mobley HLT, Pearson MM. Pathogenesis of Proteus mirabilis Infection. EcoSal Plus. 2018 Feb;8(1)PubMed PMID: 29424333; NIHMSID: NIHMS925686; PubMed Central PMCID: PMC5880328.


Packiriswamy N, Gandy J, Smith SN, Mobley HLT, Sordillo LM, Subashchandrabose S. Distinct Signature of Oxylipid Mediators of Inflammation during Infection and Asymptomatic Colonization by E coli in the Urinary Bladder. Mediators Inflamm. 2017;2017:4207928. PubMed PMID: 29445256; PubMed Central PMCID: PMC5763092.

Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ,Tamayo-Castillo G, Sherman DH, Mobley HLT. Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments. Chem Commun (Camb). 2017 Nov 28;53(95):12778-12781. PubMed PMID: 29139494; NIHMSID: NIHMS920854; PubMed Central PMCID: PMC5706644.

Alteri CJ, Himpsl SD, Zhu K, Hershey HL, Musili N, Miller JE, Mobley HLT. Subtle variation within conserved effector operon gene products contributes to T6SS-mediated killing and immunity. PLoS Pathog. 2017 Nov;13(11):e1006729. PubMed PMID: 29155899; PubMed Central PMCID: PMC5714391.

Waack U, Johnson TL, Chedid K, Xi C, Simmons LA, Mobley HLT, Sandkvist M. Targeting the Type II Secretion System: Development, Optimization, and Validation of a High-Throughput Screen for the Identification of Small Molecule Inhibitors. Front Cell Infect Microbiol. 2017;7:380. PubMed PMID: 28894700; PubMed Central PMCID: PMC5581314.

Anderson MT, Mitchell LA, Mobley HLT. Cysteine Biosynthesis Controls Serratia marcescens Phospholipase Activity. J Bacteriol. 2017 Aug 15;199(16)PubMed PMID: 28559296; PubMed Central PMCID: PMC5527384.

Armbruster CE, Forsyth-DeOrnellas V, Johnson AO, Smith SN, Zhao L, Wu W, Mobley HLT. Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirements. PLoS Pathog. 2017 Jun;13(6):e1006434. PubMed PMID: 28614382; PubMed Central PMCID: PMC5484520.

Anderson MT, Mitchell LA, Zhao L, Mobley HLT. Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens Bacteremia. MBio. 2017 May 23;8(3)PubMed PMID: 28536292; PubMed Central PMCID: PMC5442460.

Armbruster CE, Prenovost K, Mobley HL, Mody L. How Often Do Clinically Diagnosed Catheter-Associated Urinary Tract Infections in Nursing Homes Meet Standardized Criteria?. J Am Geriatr Soc. 2017 Feb;65(2):395-401. PubMed PMID: 27858954; NIHMSID: NIHMS802726; PubMed Central PMCID: PMC5310979.

Armbruster CE, Smith SN, Johnson AO, DeOrnellas V, Eaton KA, Yep A, Mody L, Wu W, Mobley HL . The Pathogenic Potential of Proteus mirabilis Is Enhanced by Other Uropathogens during Polymicrobial Urinary Tract Infection. Infect Immun. 2017 Feb;85(2)PubMed PMID: 27895127; PubMed Central PMCID: PMC5278182.


Mike LA, Smith SN, Sumner CA, Eaton KA, Mobley HL. Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13468-13473. PubMed PMID: 27821778; PubMed Central PMCID: PMC5127358.

Kaper JB, Flajnik MF, Mobley HL. Editorial: Infection and immunity research at the University of Maryland, Baltimore. Pathog Dis. 2016 Nov;74(8)PubMed PMID: 27702794.

Alteri CJ, Mobley HL. The Versatile Type VI Secretion System. Microbiol Spectr. 2016 Apr;4(2)PubMed PMID: 27227310; NIHMSID: NIHMS752947; PubMed Central PMCID: PMC4887148.

Mobley HL. Measuring Escherichia coli Gene Expression during Human Urinary Tract Infections. Pathogens. 2016 Jan 15;5(1)PubMed PMID: 26784237; PubMed Central PMCID: PMC4810128.

Engstrom MD, Mobley HL. Regulation of Expression of Uropathogenic Escherichia coli Nonfimbrial Adhesin TosA by PapB Homolog TosR in Conjunction with H-NS and Lrp. Infect Immun. 2016 Jan 11;84(3):811-21. PubMed PMID: 26755158; PubMed Central PMCID: PMC4771353.

Subashchandrabose S, Smith S, DeOrnellas V, Crepin S, Kole M, Zahdeh C, Mobley HL. Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection. mSphere. 2016 Jan-Feb;1(1)PubMed PMID: 27303682; PubMed Central PMCID: PMC4863628.