The Mobley Lab is hiring! The lab is seeking Postdoctoral Fellows to join a clinical UTI research team to measure bacterial global gene expression and growth rates during human infection. Interested applicants can submit application materials following the instructions provided here: https://careers.umich.edu/job_detail/215579/research-fellow-mobley-lab

Welcome!

The Mobley Lab was established in 1984 in the Division of Infectious Diseases at The University of Maryland School of Medicine in Baltimore. The lab moved to The Department of Microbiology and Immunology at The University of Michigan Medical School in Ann Arbor, Michigan in the summer of 2004. The Mobley Lab is comprises research professors, research technicians, undergraduates, graduate/doctoral students, and postdoctoral fellows dedicated to performing cutting edge research in the field of bacteriology. Since its inception, the lab has produced over 275 publications and trained more than 70 graduate students and postdoctoral fellows.

Mobley Lab, ASM Microbe 2022, Washington, DC

Mobley Lab, August 2018

-Molecular mechanisms of uropathogenesis

-Vaccine to prevent E. coli urinary tract infection

-E. coli virulence gene expression during clinical UTIs in women

-Virulence and fitness factors of Gram-negative bacteremia

Recent News and Announcements

June 2022: The Mobley Lab attends ASM Microbe 2022 in Washington, D.C. The following presentations were given

by members of the lab:

"ArcAB Optimizes Metabolism During Bacteremia" by Aric Brown as a Poster Talk

"Transcriptional Regulation of Proteus mirabilis Urease: New Insights Into an Old Target" by Madison Fitzgerald as a Poster Presentation

"Aerobactin Receptor IutA is an Effective Vaccine Antigen Against Escherichia coli and Generates a Unique Antibody Epitope Profile During Urinary Tract Infection" by Valerie Forsyth as a Poster Presentation

"Iron Restriction Induces Motility in Uropathogenic Escherichia coli" by Dr. Arwen Frick-Cheng as a Poster Presentation

"Contributions Of Diverse Capsule Types To Serratia marcescens Infection" by Stephanie Himpsl as a Poster Presentation

"Organ Agar Reveals Physiologically Relevant Urinary Fitness Factors for Proteus mirabilis" by Sara Smith as a Poster Presentation

"Mrpj Controls Proteus mirabilis Virulence Through Both Mr/p Fimbriae and the Larger Mrpj Regulon" by Dr. Melanie Pearson as a Poster Presentation

"Amino Acid Uptake is Highly Conserved and Fuels Uropathogenesis Mechanisms of E. coli" by Dr. Allyson Shea as a Symposium Talk


Mobley Lab, ASM Microbe 2022

Washington, D.C.

May 2022: "Ferric Citrate Uptake Is a Virulence Factor in Uropathogenic Escherichia coli" is published in mBio.

Figure 1A from Frick-Cheng et al., 2022 depicting the heme receptors, siderophores, and siderophore receptors that have been found in uropathogenic E. coli (UPEC) overall and specifically in the clinical strains CFT073 and HM7.

April 2022: "The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection" is published in Microbiology and Molecular Biology Reviews.

Figure 1 from Brown et al., 2022 overviewing the activation and function of the two-component regulatory system ArcAB found in facultatively anaerobic bacteria, including many pathogens studied in the Mobley lab.

March 2022: "Identification of distinct capsule types associated with Serratia marcescens infection isolates" is published

in PLoS Pathogens.

Figure 2 from Anderson et al., 2022 showcasing the genes encoding varying capsule types identified in strains of Serratia marcescens.

March 2022: "CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection" is published in Microbiology Spectrum.

February 2022: Congratulations to Madison Fitzgerald on receiving a Ruth L. Kirschstein Predoctoral Individual National Research Service Award (F31) titled "Systematic analysis of Proteus mirabilis transcriptional regulators that drive uropathogenesis" from the National Institute of Diabetes and Digestive and Kidney Diseases! This grant provides Madison with 3 years of funding support.

December 2021: "Loss of an Intimin-Like Protein Encoded on a Uropathogenic E. coli Pathogenicity Island Reduces Inflammation and Affects Interactions with the Urothelium" is published in Infection and Immunity.

Figure 1 from Shea et al., 2020 depicts the predicted host cell interaction domains in the intimin-like adhesion locus, which is highly conserved among uropathogenic E. coli

October 2021: Dr. Arwen Frick-Cheng presented her work, Ferric Citrate Uptake is a Virulence Factor in Uropathogenic Escherichia coli, as a part of UTI Hour seminar series with UTIGA (UTI Global Alliance).

September 2021: Drs. Arwen Frick-Cheng and Allyson Shea virtually attend and present posters at the thirteenth Cold Spring Harbor meeting on Microbial Pathogenesis and Host Response with Dr. Shea also giving a lecture on her work.

September 2021: Drs. Arwen Frick-Cheng, Melanie Pearson, and Geoffrey Severin attend the 2021 Midwest Microbial Pathogenesis Conference at Michigan State University to present their research.

Drs. Arwen Frick-Cheng and Allyson Shea with former Mobley lab member Beth Ottosen, Ph.D. candidate at MSU.

Dr. Arwen Frick-Cheng presents her poster, "Iron Restriction Induces Motility in Uropathogenic Eschericihia coli."

Dr. Allyson Shea presents her poster, "Carbon source utilization is a primary indicator of colonization severity for uropathogenic Escherichia coli during UTI.

Dr. Geoffrey Severin presents his poster, "Characterization of Fitness Genes Contributing to Citrobacter freundii Bacteremia."

July 2021: Congratulations to Dr. Sapna Pahil on accepting a position as a tenure-track Assistant Professor position in the Department of Medical Microbiology at the Postgraduate Institute of Medical Education and Research in Chandigarh, India!

July 2021: Congratulations to Dr. Amanda Starr on accepting a position at Texas Tech University!

July 2021: "Replication Dynamics for Six Gram-Negative Bacterial Species during Bloodstream Infection" is published in mBio.

June 2021: Congratulations to Dr. Laura Mike on accepting a position as Assistant Professor in the Department of Medical Microbiology and Immunology at the University of Toledo!

June 2021: The lab virtually attends World Microbe 2021.

April 2021: Aric Brown is awarded a two year American Heart Association Predoctoral Fellowship for his proposal, "The two-component system ArcAB contributes to bacterial fitness during Gram-negative bacteremia."