The Mobley Lab was established in 1984 in the Division of Infectious Diseases at The University of Maryland School of Medicine in Baltimore. The lab moved to The Department of Microbiology and Immunology at The University of Michigan Medical School in Ann Arbor, Michigan in the summer of 2004. The Mobley Lab comprises research professors, research technicians, undergraduates, graduate/doctoral students, and postdoctoral fellows dedicated to performing cutting edge research in the field of bacteriology. Since its inception, the lab has produced over 275 publications and trained more than 70 graduate students and postdoctoral fellows.

Mobley Lab, ASM Microbe 2022, Washington, DC

Mobley Lab, August 2018

-Molecular mechanisms of uropathogenesis

-Vaccine to prevent E. coli urinary tract infection

-E. coli virulence gene expression during clinical UTIs in women

-Virulence and fitness factors of Gram-negative bacteremia

Recent News and Announcements

January 2023: Dr. Surbhi Gupta joins the laboratory as a postdoctoral fellow. Welcome!

January 2023: Maggie Gaca joins the laboratory as a research technician. Welcome!

January 2023: Tad Eichler joins the laboratory as a research technician. Welcome!

January 2023: Congratulations to Dr. Allyson Shea on accepting a position as an assistant professor at the University of South Alabama!

December 2022: Dr. Santosh Paudel joins the laboratory as a postdoctoral fellow. Welcome!

November 2022: Dr. Mobley is interviewed as part of an article for Medical News Today regarding development of a UTI vaccine.

November 2022: "Phenotypic Assessment of Clinical Escherichia coli Isolates Predicts Uropathogenic Potential" is published in mSystems.

Panel A of Figure 7 from Shea and Frick-Cheng, et al. 2022 summarizing the correlation between bladder or urine colonization in mice by 13 clinical strains of uropathogenic E. coli and a series of phenotypic assays used to characterize the strains.

November 2022: Dr. Shiuhyang Kuo joins the laboratory as a research technician. Welcome!

November 2022: Christina Kiser joins the laboratory as a research technician. Welcome!

November 2022: "Construction of an Ordered Transposon Library for Uropathogenic Proteus mirabilis HI4320" is published in Microbiology Spectrum.

Figure 1 from Pearson, et al. 2022 mapping the insertion sites of

the transposon library for Proteus mirabilis HI4320.

(Left to Right) Drs. Allyson Shea, Melanie Pearson, and Geoffrey Severin at MMPC in Madison, Wisconsin

September 2022: Members of the Mobley Lab attended the 28th Annual Midwest Microbial Pathogenesis Conference (MMPC) at the University of Wisconsin–Madison. The following posters were presented by the lab (attendees in underline):

"ABC Importers: The Underestimated Contributors to Uropathogenesis"

by Allyson Shea, Arwen Frick-Cheng, Sara Smith, and Harry LT Mobley

"Organ Agar Reveals Physiologically Relevant Urinary Fitness Factors for Proteus mirabilis" by Melanie Pearson, Sara N. Smith, Sapna Pahil, and Harry L.T. Mobley

"Shikimate Biosynthesis Contributes to Citrobacter freundii Fitness During Bacteremia" by Geoff Severin, Aric N. Brown, Sara N. Smith, and Harry L. T. Mobley

September 2022: Congratulations to Dr. Allyson Shea on being awarded Outstanding Postdoctoral Fellow Award from the University of Michigan!

Dr. Allyson Shea

August 2022: The laboratory welcomes Dr. Dawid Gmiter as a visiting scholar from Jan Kochanowski University in Kielce, Poland.

August 2022: Congratulations to Dr. Arwen Frick-Cheng on accepting a position as a Senior Scientist in the laboratory of Dr. Melanie Ohi at the Life Sciences Institute!

July 2022: Members of the Mobley Lab virtually attend a conference through the Urinary Tract Infection Global Alliance (UTIGA). Dr. Mobley was invited to give a talk titled, "Movin’ On Up: Bladder to Kidney to Bloodstream." Dr. Melanie Pearson presented her work as a talk selected from poster abstracts. Madison Fitzgerald, Valerie Forsyth, Dr. Pearson, Dr. Allyson Shea, and Sara Smith also presented posters throughout the conference. Congratulations to Dr. Pearson on being named a communication officer for UTIGA!

June 2022: The Mobley Lab attends ASM Microbe 2022 in Washington, D.C. The following presentations were given

by members of the lab:

"ArcAB Optimizes Metabolism During Bacteremia" by Aric Brown as a Poster Talk

"Transcriptional Regulation of Proteus mirabilis Urease: New Insights Into an Old Target" by Madison Fitzgerald as a Poster Presentation

"Aerobactin Receptor IutA is an Effective Vaccine Antigen Against Escherichia coli and Generates a Unique Antibody Epitope Profile During Urinary Tract Infection" by Valerie Forsyth as a Poster Presentation

"Iron Restriction Induces Motility in Uropathogenic Escherichia coli" by Dr. Arwen Frick-Cheng as a Poster Presentation

"Contributions Of Diverse Capsule Types To Serratia marcescens Infection" by Stephanie Himpsl as a Poster Presentation

"Organ Agar Reveals Physiologically Relevant Urinary Fitness Factors for Proteus mirabilis" by Sara Smith as a Poster Presentation

"Mrpj Controls Proteus mirabilis Virulence Through Both Mr/p Fimbriae and the Larger Mrpj Regulon" by Dr. Melanie Pearson as a Poster Presentation

"Amino Acid Uptake is Highly Conserved and Fuels Uropathogenesis Mechanisms of E. coli" by Dr. Allyson Shea as a Symposium Talk

Mobley Lab, ASM Microbe 2022

Washington, D.C.

May 2022: "Ferric Citrate Uptake Is a Virulence Factor in Uropathogenic Escherichia coli" is published in mBio.

Figure 1A from Frick-Cheng et al., 2022 depicting the heme receptors, siderophores, and siderophore receptors that have been found in uropathogenic E. coli (UPEC) overall and specifically in the clinical strains CFT073 and HM7.

April 2022: "The ArcAB Two-Component System: Function in Metabolism, Redox Control, and Infection" is published in Microbiology and Molecular Biology Reviews.

Figure 1 from Brown et al., 2022 overviewing the activation and function of the two-component regulatory system ArcAB found in facultatively anaerobic bacteria, including many pathogens studied in the Mobley lab.