Welcome!

The Mobley Lab was established in 1984 in the Division of Infectious Diseases at The University of Maryland School of Medicine in Baltimore. The lab moved to The Department of Microbiology and Immunology at The University of Michigan Medical School in Ann Arbor, Michigan in the summer of 2004. The Mobley Lab is comprised of research professors, research technicians, undergraduates, graduate/doctoral students, and postdoctoral fellows dedicated to performing cutting edge research in the field of bacteriology. Since its inception, the lab has produced over 250 publications and trained more than 70 graduate students and postdoctoral fellows.

Mobley Lab, August 2018

-Molecular mechanisms of uropathogenesis

-Vaccine to prevent E. coli urinary tract infection

-E. coli virulence gene expression during clinical UTIs in women

-Virulence and fitness factors of Gram-negative bacteremia

Recent News and Announcements

August 2020: The Critical Assessments of Protein Structure Predictions (CASP) 2020 competition selected the structure for MrpH (part of a recent Mobley lab publication in PLoS Pathogens) as a target to develop better model prediction tools.

May 2020: "Transposon Insertion Site Sequencing of Providencia Stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements" is published in mSphere.

May 2020: The vaccine group of the Mobley lab is featured on an episode of the podcast This Week in Microbiology (TWiM) for the recent publication "Optimization of an experimental vaccine to prevent Escherichia coli urinary tract infection."

May 2020: "The Serratia marcescens siderophore, serratiochelin, is necessary for full virulence during bloodstream infection" is published in Infection and Immunity.

May 2020: "Identification of Escherichia coli CFT073 fitness factors during urinary tract infection using an ordered transposon library" is published in Applied and Environmental Microbiology.

April 2020: "Optimization of an experimental vaccine to prevent Escherichia coli urinary tract infection" is published in mBio.

April 2020: Dr. Arwen Frick-Cheng serves as an author on a recent publication in Infection and Immunity from her graduate work.

February 2020: "The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI" is published in PLoS Pathogens.