The Mobley Lab was established in 1984 in the Division of Infectious Diseases at The University of Maryland School of Medicine in Baltimore. The lab moved to The Department of Microbiology and Immunology at The University of Michigan Medical School in Ann Arbor, Michigan in the summer of 2004. The Mobley Lab is comprised of research professors, research technicians, undergraduates, graduate/doctoral students, and postdoctoral fellows dedicated to performing cutting edge research in the field of bacteriology. Since its inception, the lab has produced over 250 publications and trained more than 70 graduate students and postdoctoral fellows.

Mobley Lab, August 2018

-Molecular mechanisms of uropathogenesis

-Vaccine to prevent E. coli urinary tract infection

-E. coli virulence gene expression during clinical UTIs in women

-Virulence and fitness factors of Gram-negative bacteremia

Recent News and Announcements

November 2019: Dr. Arwen Frick-Cheng serves as an author on a recent publication in Infection and Immunity from her graduate work.

November 2019: "Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut" is published in Nature Microbiology.

November 2019: "The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii" is published in Molecular Microbiology.

October 2019: "Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with UTIs" is published in eLife.

August 2019: The Encyclopedia of Microbiology, 4th Edition is published. Dr. Mobley served on the editorial board for this edition, and Danelle Weakland authored a section titled "Bacterial Iron Acquisition Strategies."

August 2019: Dr. Amanda Starr joins the lab as a postdoctoral fellow. Welcome!

August 2019: "The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection" is published in PLoS Pathogens.

August 2019: "Sulfur assimilation alters flagellar function and modulates the gene expression landscape of Serratia marcescens" is published in mSystems.

August 2019: A podcast interview by microTalk from ASM titled "Urine Trouble: Urinary Tract Infections with Harry Mobley" is released.

July 2019: Congratulations to Christina Sarkissian Milner, M.S. on accepting a position as a Research Associate - Molecular Biology at Arbor Biosciences in Ann Arbor, Michigian!

July 2019: "Proteus mirablis Methods and Protocols" is published as part of the Methods in Molecular Biology book series with Dr. Melanie Pearson serving as Editor.

July 2019: " UTI patients have pre-existing antigen-specific antibody titers against UTI vaccine antigens" is published in Vaccine.

July 2019: Congratulations to Dr. Allyson Shea on receiving a NRSA Individual Postdoctoral Fellowship (F32) titled "Characterization of pathogen nutrient acquisition and transport systems required during UTI" from the National Institute of Allergy and Infectious Diseases. This grant provides Allyson with three years of support.

July 2019: A commentary titled "mSphere of Influence: Systematically Decoding Microbial Chemical Communication" and written by Dr. Laura Mike is published in mSphere.

July 2019: Dr. Arwen Frick-Cheng serves as an author on two recent publications from her graduate work in eLife and mBio.

June 2019: Drs. Harry Mobley, Melanie Pearson, and Laura Mike attend the 2019 Clinical and Scientific Advances in Urinary Tract Infections Conference in Columbus, Ohio. Melanie and Laura both presented posters, and Laura gave an additional poster talk.

June 2019: Christina Sarkissian Milner and the lab's work presented at Microbe 2019 is featured in an article by MedPage Today.

June 2019: The Mobley lab attends ASM Microbe 2019 in San Francisco. Dr. Mark Anderson, Michael Breed, Aric Brown, Dr. Arwen Frick-Cheng, Dr. Sébastien Crépin, Valerie Forsyth, Stephanie Himpsl, Dr. Melanie Pearson, Christina Sarkissian Milner, Dr. Allyson Shea, Sara Smith, and Danelle Weakland present posters. Danelle presents a symposium talk, Michael and Aric have rapid fire presentations, and Allyson gives an additional poster talk. Danelle and Allyson also received ASM travel awards, and Aric received a conference travel grant from the University of Michigan Rackham Graduate School. This is the 35th ASM General Meeting/Microbe the lab has attended as a group.

June 2019: "Flexible metabolism and suppression of latent enzymes are important for E. coli adaptation to diverse environments within the host" is published in Journal of Bacteriology.

May 2019: Congratulations to Madison Fitzgerald for being accepted into the Michigan Predoctoral Training Program in Genetics! This is one of the oldest NIH supported training programs and provides financial support as well as a rigorous curriculum, interactive seminars, and an annual retreat.

May 2019: Congratulations to Dr. Laura Mike on receiving a K22 Career Transition Award titled "Functional Genetic Analysis of Klebsiella pneumoniae Hypervirulence" from the National Institute of Allergy and Infectious Diseases!

May 2019: Lab manager and research technician Stephanie Himpsl has been selected to receive an Endowment for the Basic Sciences Research Staff Award, which is given in recognition of outstanding research productivity and innovation over the past year at the University of Michigan Medical School. Stephanie is an outstanding scientist serving as co-author on 16 papers, including two as first author and three as co-first author. She has been a contributing author or presenting author on 22 national meeting abstracts. Congratulations!