Welcome!

The Mobley Lab was established in 1984 in the Division of Infectious Diseases at The University of Maryland School of Medicine in Baltimore. The lab moved to The Department of Microbiology and Immunology at The University of Michigan Medical School in Ann Arbor, Michigan in the summer of 2004. The Mobley Lab is comprised of research professors, research technicians, undergraduates, graduate/doctoral students, and postdoctoral fellows dedicated to performing cutting edge research in the field of bacteriology. Since its inception, the lab has produced over 250 publications and trained more than 70 graduate students and postdoctoral fellows.

Mobley Lab, August 2018

-Molecular mechanisms of uropathogenesis

-Vaccine to prevent E. coli urinary tract infection

-E. coli virulence gene expression during clinical UTIs in women

-Virulence and fitness factors of Gram-negative bacteremia

Recent News and Announcements

May 2020: "Transposon Insertion Site Sequencing of Providencia Stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements" is published in mSphere.

May 2020: The vaccine group of the Mobley lab is featured on an episode of the podcast This Week in Microbiology (TWiM) for the recent publication "Optimization of an experimental vaccine to prevent Escherichia coli urinary tract infection."

May 2020: "The Serratia marcescens siderophore, serratiochelin, is necessary for full virulence during bloodstream infection" is published in Infection and Immunity.

May 2020: "Identification of Escherichia coli CFT073 fitness factors during urinary tract infection using an ordered transposon library" is published in Applied and Environmental Microbiology.

April 2020: "Optimization of an experimental vaccine to prevent Escherichia coli urinary tract infection" is published in mBio.

April 2020: Dr. Arwen Frick-Cheng serves as an author on a recent publication in Infection and Immunity from her graduate work.

February 2020: "The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI" is published in PLoS Pathogens.

November 2019: Dr. Arwen Frick-Cheng serves as an author on a recent publication in Infection and Immunity from her graduate work.

November 2019: "Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut" is published in Nature Microbiology.

November 2019: "The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii" is published in Molecular Microbiology.

October 2019: "Genetically diverse uropathogenic Escherichia coli adopt a common transcriptional program in patients with UTIs" is published in eLife.

August 2019: The Encyclopedia of Microbiology, 4th Edition is published. Dr. Mobley served on the editorial board for this edition, and Danelle Weakland authored a section titled "Bacterial Iron Acquisition Strategies."

August 2019: Dr. Amanda Starr joins the lab as a postdoctoral fellow. Welcome!

August 2019: "The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection" is published in PLoS Pathogens.

August 2019: "Sulfur assimilation alters flagellar function and modulates the gene expression landscape of Serratia marcescens" is published in mSystems.

August 2019: A podcast interview by microTalk from ASM titled "Urine Trouble: Urinary Tract Infections with Harry Mobley" is released.